Methods for high-dimensonal analysis of cells dissociated from cyropreserved synovial tissue Academic Article uri icon

Overview

MeSH Major

  • Arthritis, Rheumatoid

abstract

  • We have established a robust protocol to acquire viable cells from cryopreserved synovial tissue with intact transcriptomes and cell surface phenotypes. A centralized pipeline to generate multiple high-dimensional analyses of synovial tissue samples collected across a collaborative network was developed. Integrated analysis of such datasets from large patient cohorts may help define molecular heterogeneity within RA pathology and identify new therapeutic targets and biomarkers.

authors

publication date

  • July 11, 2018

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC6042350

Digital Object Identifier (DOI)

  • 10.1186/s13075-018-1631-y

PubMed ID

  • 29996944

Additional Document Info

start page

  • 139

volume

  • 20

number

  • 1