Rural residence and chronic obstructive pulmonary disease exacerbations: Analysis of the SPIROMICS cohort
Endothelial Growth Factors
Gene Expression Regulation
Intercellular Signaling Peptides and Proteins
Rural residence is independently associated with increased odds and incidence of total, but not severe COPD exacerbations. These associations are not fully explained by agriculture-related exposures, highlighting the need for future research into potential mechanisms of increased risk of COPD exacerbations in the rural population.