A phase 1 study of ADI-PEG 20 and modified FOLFOX6 in patients with advanced hepatocellular carcinoma and other gastrointestinal malignancies Academic Article uri icon

Overview

MeSH Major

  • Brain Neoplasms
  • Indoles
  • Melanoma
  • Proto-Oncogene Proteins B-raf
  • Sulfonamides

abstract

  • Arginine depletion interferes with pyrimidine metabolism as well as DNA damage repair pathways. Preclinical data indicates that pairing pegylated arginine deiminase (ADI-PEG 20) with fluoropyrimidines or platinum enhances cytotoxicity in vitro and in vivo in arginine auxotrophs.

publication date

  • July 3, 2018

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1007/s00280-018-3635-3

PubMed ID

  • 29971467

Additional Document Info

start page

  • 1

end page

  • 12