Prospective Evaluation of Germline Alterations in Patients With Exocrine Pancreatic Neoplasms Academic Article uri icon

Overview

MeSH Major

  • Chromosomes, Human, Pair 4
  • Colonic Neoplasms
  • Germ-Line Mutation
  • Neoplasm Metastasis

abstract

  • PGAs frequently occur in pancreas exocrine neoplasms and involve multiple genes beyond those previously associated with hereditary pancreatic cancer. These PGAs are therapeutically actionable in about 5% to 10% of patients. These data support routinely offering GT in all pancreatic ductal adenocarcimona patients with a broad panel of known hereditary cancer predisposition genes.

authors

publication date

  • October 2018

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC6186514

Digital Object Identifier (DOI)

  • 10.1093/jnci/djy024

PubMed ID

  • 29506128

Additional Document Info

start page

  • 1067

end page

  • 1074

volume

  • 110

number

  • 10