Association between acute respiratory disease events and the MUC5B promoter polymorphism in smokers Academic Article uri icon


MeSH Major

  • Inflammation
  • Mitochondria


  • © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted. A single-nucleotide polymorphism (rs35705950) in the mucin 5B (MUC5B) gene promoter is associated with pulmonary fibrosis and interstitial features on chest CT but may also have beneficial effects. In non-Hispanic whites in the COPDGene cohort with interstitial features (n=454), the MUC5B promoter polymorphism was associated with a 61% lower odds of a prospectively reported acute respiratory disease event (P=0.001), a longer time-to-first event (HR=0.57; P=0.006) and 40% fewer events (P=0.016). The MUC5B promoter polymorphism may have a beneficial effect on the risk of acute respiratory disease events in smokers with interstitial CT features.

publication date

  • February 13, 2018



  • Academic Article



  • eng

Digital Object Identifier (DOI)

  • 10.1136/thoraxjnl-2017-211208

PubMed ID

  • 29440587

Additional Document Info