Clinical Outcomes With Ring Sideroblasts and SF3B1 Mutations in Myelodysplastic Syndromes: MDS Clinical Research Consortium Analysis Academic Article uri icon

Overview

MeSH Major

  • Chromosome Deletion
  • Chromosomes, Human, Pair 5
  • Leukemia, Myeloid, Acute
  • Myelodysplastic Syndromes

abstract

  • SF3B1 mutations in MDS are commonly associated with RS and show better outcomes, with mutated/positive RS presence being significantly better than isolated RS or presence of mutation or neither. Patients with mutation showed better responses to an erythroid-stimulating agent. A new categorization incorporating SF3B1 mutation status, regardless of RS percentage, shows clinical value.

publication date

  • January 2018

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1016/j.clml.2018.05.016

PubMed ID

  • 29937400

Additional Document Info