Next-generation sequencing identifies gene mutations that are predictive of malignancy in residual needle rinses collected from fine-needle aspirations of thyroid nodules Academic Article uri icon

Overview

MeSH Major

  • Carcinoma, Renal Cell
  • Endoscopic Ultrasound-Guided Fine Needle Aspiration
  • Kidney Neoplasms
  • Pancreatic Neoplasms

abstract

  • - Our data demonstrate that residual thyroid FNA needle rinses are an adequate source of material for molecular diagnostic testing. Importantly, detection of a mutation implicated in thyroid malignancy was predictive of the final surgical diagnosis and clinical outcome. Our strategy to triage thyroid nodules with indeterminate cytology with molecular testing eliminates the need to perform additional FNA passes into dedicated media or to schedule additional invasive procedures. Further investigation with a larger sample size to confirm the clinical utility of our proposed strategy is underway.

publication date

  • February 2018

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.5858/arpa.2017-0136-OA

PubMed ID

  • 28537807

Additional Document Info

start page

  • 178

end page

  • 183

volume

  • 142

number

  • 2