Leptin regulation of the p53-HIF1α/PKM2-Aromatase axis in breast adipose stromal cells: A novel mechanism for the obesity-breast cancer link Academic Article uri icon

Overview

MeSH Major

  • Breast Neoplasms
  • Carcinoma, Intraductal, Noninfiltrating
  • Carcinoma, Lobular
  • Mastectomy, Segmental
  • Neoplasm Recurrence, Local

abstract

  • Overall, findings demonstrate a novel mechanism for the obesity-associated increase in aromatase in ASCs of the breast and support the study of lifestyle interventions, including weight management, which may reduce breast cancer risk via effects on this pathway.

publication date

  • April 2018

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC5936686

Digital Object Identifier (DOI)

  • 10.1038/ijo.2017.273

PubMed ID

  • 29104286

Additional Document Info

start page

  • 711

end page

  • 720

volume

  • 42

number

  • 4