BDNF activates an NFI-dependent neurodevelopmental timing program by sequestering NFATc4 Academic Article uri icon

Overview

MeSH Major

  • DNA
  • Glutamate Decarboxylase
  • Olfactory Bulb
  • Promoter Regions, Genetic
  • Smell
  • Tyrosine 3-Monooxygenase

abstract

  • We show that BDNF regulates the timing of neurodevelopment via a novel mechanism of extranuclear sequestration of NFATc4 in Golgi. This leads to accelerated derepression of an NFI temporal occupancy gene program in cerebellar granule cells that includes Bdnf itself, revealing an autoregulatory loop within the program driven by BDNF and NFATc4.

publication date

  • April 15, 2018

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC5896935

Digital Object Identifier (DOI)

  • 10.1091/mbc.E16-08-0595

PubMed ID

  • 29467254

Additional Document Info

start page

  • 975

end page

  • 987

volume

  • 29

number

  • 8