Regulation of the Cell Biology of Antigen Cross-Presentation Academic Article uri icon


MeSH Major

  • Apoptosis
  • Epithelial Cells
  • Homeostasis
  • Intestinal Mucosa
  • Phagocytes


  • Antigen cross-presentation is an adaptation of the cellular process of loading MHC-I molecules with endogenous peptides during their biosynthesis within the endoplasmic reticulum. Cross-presented peptides derive from internalized proteins, microbial pathogens, and transformed or dying cells. The physical separation of internalized cargo from the endoplasmic reticulum, where the machinery for assembling peptide-MHC-I complexes resides, poses a challenge. To solve this problem, deliberate rewiring of organelle communication within cells is necessary to prepare for cross-presentation, and different endocytic receptors and vesicular traffic patterns customize the emergent cross-presentation compartment to the nature of the peptide source. Three distinct pathways of vesicular traffic converge to form the ideal cross-presentation compartment, each regulated differently to supply a unique component that enables cross-presentation of a diverse repertoire of peptides. Delivery of centerpiece MHC-I molecules is the critical step regulated by microbe-sensitive Toll-like receptors. Defining the subcellular sources of MHC-I and identifying sites of peptide loading during cross-presentation remain key challenges.

publication date

  • April 26, 2018



  • Academic Article



  • eng

Digital Object Identifier (DOI)

  • 10.1146/annurev-immunol-041015-055523

PubMed ID

  • 29490164

Additional Document Info

start page

  • 717

end page

  • 753


  • 36