Lower serum IgA is associated with COPD exacerbation risk in SPIROMICS Academic Article uri icon

Overview

MeSH Major

  • Epigenesis, Genetic
  • Epithelium
  • Smoking

abstract

  • Subnormal serum IgA levels were associated with increased risk for acute exacerbations, supporting mildly impaired IgA levels as a contributing factor in COPD morbidity. Additionally, a dose-response relationship between lower serum IgA and number of exacerbations was found among individuals with serum IgA in the lowest decile, further supporting the link between serum IgA and exacerbation risk. Future COPD studies should more comprehensively characterize immune status to define the clinical relevance of these findings and their potential for therapeutic correction.

publication date

  • January 2018

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1371/journal.pone.0194924

PubMed ID

  • 29649230

Additional Document Info

start page

  • e0194924

volume

  • 13

number

  • 4