Targeting the Proteostasis Network for Mycobacterial Drug Discovery Academic Article uri icon

Overview

MeSH Major

  • Charcoal
  • Mycobacterium tuberculosis

abstract

  • Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains one of the world's deadliest infectious diseases and urgently requires new antibiotics to treat drug-resistant strains and to decrease the duration of therapy. During infection, Mtb encounters numerous stresses associated with host immunity, including hypoxia, reactive oxygen and nitrogen species, mild acidity, nutrient starvation, and metal sequestration and intoxication. The Mtb proteostasis network, composed of chaperones, proteases, and a eukaryotic-like proteasome, provides protection from stresses and chemistries of host immunity by maintaining the integrity of the mycobacterial proteome. In this Review, we explore the proteostasis network as a noncanonical target for antibacterial drug discovery.

publication date

  • April 13, 2018

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC5902792

Digital Object Identifier (DOI)

  • 10.1021/acsinfecdis.7b00231

PubMed ID

  • 29465983

Additional Document Info

start page

  • 478

end page

  • 498

volume

  • 4

number

  • 4