Cancer immunotherapy using checkpoint blockade Review uri icon

Overview

MeSH Major

  • Antibodies
  • CTLA-4 Antigen
  • Immunotherapy
  • Neoplasms
  • Programmed Cell Death 1 Receptor

abstract

  • The release of negative regulators of immune activation (immune checkpoints) that limit antitumor responses has resulted in unprecedented rates of long-lasting tumor responses in patients with a variety of cancers. This can be achieved by antibodies blocking the cytotoxic T lymphocyte-associated protein 4 (CTLA-4) or the programmed cell death 1 (PD-1) pathway, either alone or in combination. The main premise for inducing an immune response is the preexistence of antitumor T cells that were limited by specific immune checkpoints. Most patients who have tumor responses maintain long-lasting disease control, yet one-third of patients relapse. Mechanisms of acquired resistance are currently poorly understood, but evidence points to alterations that converge on the antigen presentation and interferon-γ signaling pathways. New-generation combinatorial therapies may overcome resistance mechanisms to immune checkpoint therapy.

publication date

  • March 23, 2018

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1126/science.aar4060

PubMed ID

  • 29567705

Additional Document Info

start page

  • 1350

end page

  • 1355

volume

  • 359

number

  • 6382