Carbapenemase-Producing Organisms: A Global Scourge Academic Article uri icon


MeSH Major

  • Anti-Bacterial Agents
  • Staphylococcal Infections
  • Staphylococcus intermedius


  • The dramatic increase in the prevalence and clinical impact of infections caused by bacteria producing carbapenemases is a global health concern. Carbapenemase production is especially problematic when encountered in members of the family Enterobacteriaceae. Due to their ability to readily spread and colonize patients in healthcare environments, preventing the transmission of these organisms is a major public health initiative and coordinated international effort are needed. Central to the treatment and control of carbapenemase-producing organisms (CPOs) are phenotypic (growth-/biochemical-dependent) and nucleic acid-based carbapenemase detection tests that identify carbapenemase activity directly or their associated molecular determinants. Importantly, bacterial isolates harboring carbapenemases are often resistant to multiple antibiotic classes, resulting in limited therapy options. Emerging agents, novel antibiotic combinations and treatment regimens offer promise for management of these infections. This review highlights our current understanding of CPOs with emphasis on their epidemiology, detection, treatment, and control.

publication date

  • April 3, 2018



  • Academic Article



  • eng

PubMed Central ID

  • PMC5884739

Digital Object Identifier (DOI)

  • 10.1093/cid/cix893

PubMed ID

  • 29165604

Additional Document Info

start page

  • 1290

end page

  • 1297


  • 66


  • 8