Colorectal carcinomas with isolated loss of PMS2 staining by immunohistochemistry Academic Article uri icon

Overview

MeSH Major

  • Colitis, Ischemic
  • Colon
  • Intestinal Mucosa
  • Mesenteric Vascular Occlusion
  • Mesenteric Veins
  • Neointima

abstract

  • - Unusual clinicopathologic features observed in colorectal carcinomas with isolated PMS2 loss are likely related to the high proportion of cases caused by germline mutations. Isolated PMS2-loss tumors may demonstrate more aggressive behavior than other tumors with microsatellite instability, but larger studies are needed to investigate that possibility further.

publication date

  • April 2018

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.5858/arpa.2017-0156-OA

PubMed ID

  • 29336605

Additional Document Info

start page

  • 523

end page

  • 528

volume

  • 142

number

  • 4