Characterization of metastatic urothelial carcinoma via comprehensive genomic profiling of circulating tumor DNA Academic Article uri icon


MeSH Major

  • APOBEC-1 Deaminase
  • Carcinoma, Transitional Cell
  • Clonal Evolution
  • Drug Resistance, Neoplasm
  • Mutagenesis
  • Mutation
  • Neural Cell Adhesion Molecule L1
  • Urinary Bladder Neoplasms


  • Among patients with mUC for whom no tumor tissue was available, cfDNA NGS was able to identify a similar profile of GAs for biomarker-driven clinical trials compared with tumor tissue. Despite the more aggressive clinical course, cases of mUTUC demonstrated a circulating tumor DNA genomic landscape that was similar to that of mLTUC. Cancer 2018. © 2018 American Cancer Society.

publication date

  • January 2018



  • Academic Article



  • eng

Digital Object Identifier (DOI)

  • 10.1002/cncr.31314

PubMed ID

  • 29517810

Additional Document Info