Targeting mRNA Decapping in AML Article uri icon

Overview

MeSH Major

  • Ascorbic Acid
  • DNA-Binding Proteins
  • Leukemia, Myeloid, Acute
  • Myelodysplastic Syndromes
  • Proto-Oncogene Proteins
  • Vitamins

abstract

  • © 2018 Elsevier Inc. In this issue of Cancer Cell, Yamauchi et al. identify a dependency of acute myeloid leukemia (AML) on DCPS, which catalyzes the final step of 3′-to-5′ mRNA decay and is implicated in numerous aspects of RNA metabolism. DCPS is targetable with a clinical inhibitor, underscoring the translational importance of this discovery. In this issue of Cancer Cell, Yamauchi et al. identify a dependency of acute myeloid leukemia (AML) on DCPS, which catalyzes the final step of 3′-to-5′ mRNA decay and is implicated in numerous aspects of RNA metabolism. DCPS is targetable with a clinical inhibitor, underscoring the translational importance of this discovery.

publication date

  • January 2018

Research

keywords

  • Article

Identity

Digital Object Identifier (DOI)

  • 10.1016/j.ccell.2018.02.015