Do infection patterns of human papillomavirus affect the cytologic detection of high-grade cervical lesions on papanicolaou tests?
Adenocarcinoma in Situ
Carcinoma, Squamous Cell
Cervical Intraepithelial Neoplasia
Human Papillomavirus DNA Tests
Squamous Intraepithelial Lesions of the Cervix
Uterine Cervical Neoplasms
- Our findings suggest that multigenotypic or non-16/18 hrHPV infections often produce deceptive lower-grade cytomorphology, which could result in underdiagnosis and delay of treatment. The HPV infection patterns may offer unrecognized benefit beyond HPV genotyping and should be considered during clinical risk evaluation of women with lower-grade cytology.