The autophagic network and cancer Review uri icon

Overview

MeSH Major

  • Adult Stem Cells
  • DNA Damage
  • DNA Repair
  • Embryonic Stem Cells
  • Neoplasms
  • Neoplastic Stem Cells
  • Pluripotent Stem Cells

abstract

  • Mammalian cells harness autophagy to eliminate physiological byproducts of metabolism and cope with microenvironmental perturbations. Moreover, autophagy connects cellular adaptation with extracellular circuitries that impinge on immunity and metabolism. As it links transformed and non-transformed components of the tumour microenvironment, such an autophagic network is important for cancer initiation, progression and response to therapy. Here, we discuss the mechanisms whereby the autophagic network interfaces with multiple aspects of malignant disease.

publication date

  • March 2018

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1038/s41556-018-0042-2

PubMed ID

  • 29476153

Additional Document Info

start page

  • 243

end page

  • 251

volume

  • 20

number

  • 3