Combining Quantitative Susceptibility Mapping with Automatic Zero Reference (QSM0) and Myelin Water Fraction Imaging to Quantify Iron-Related Myelin Damage in Chronic Active MS Lesions Academic Article uri icon

Overview

MeSH Major

  • Amyloid beta-Peptides
  • Blood Glucose
  • Brain
  • White Matter

abstract

  • Quantitative susceptibility mapping rim-positive lesions maintained a hyperintense rim, increased in susceptibility, and had more myelin damage compared with rim-negative lesions. Our results are consistent with the identification of chronic active MS lesions and may provide a target for therapeutic interventions to reduce myelin damage.

publication date

  • February 2018

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC5812818

Digital Object Identifier (DOI)

  • 10.3174/ajnr.A5482

PubMed ID

  • 29242359

Additional Document Info

start page

  • 303

end page

  • 310

volume

  • 39

number

  • 2