Lymphedema: Pathogenesis and Novel Therapies Article Report uri icon


MeSH Major

  • Magnetic Resonance Angiography
  • Perforator Flap
  • Reconstructive Surgical Procedures


  • Copyright ©2018 by Annual Reviews. All rights reserved. Lymphedema affects up to 1 in 6 patients who undergo treatment for a solid tumor in the United States. Its prevalence has increased as more effective oncologic therapies have improved patient survival, but there remains no definitive cure. Recent research has elucidated new details in the pathogenesis of the disease and has demonstrated that it is fundamentally an immunologic process that ultimately results in inflammation, fibroadipose deposition, impaired lymphangiogenesis, and dysfunctional lymphatic pumping. These findings have allowed for the development of novel medical and surgical therapies that may potentially alter the standard of care for a disease that has largely been treated by compression. This review seeks to provide an overview of the emerging therapies and how they can be utilized for effective management of lymphedema.

publication date

  • January 29, 2018



  • Report


Digital Object Identifier (DOI)

  • 10.1146/annurev-med-060116-022900

PubMed ID

  • 28877002

Additional Document Info

start page

  • 263

end page

  • 276


  • 69