Negative Pap tests in women with high-grade cervical lesions on follow-up biopsies: Contributing factors and role of human papillomavirus genotyping Academic Article uri icon

Overview

MeSH Major

  • Cervix Uteri
  • Cytodiagnosis
  • Diagnostic Imaging
  • Image Processing, Computer-Assisted
  • Telepathology
  • Vagina
  • Vaginal Smears

abstract

  • Our study demonstrated that 5% of women underwent co-testing with negative Pap tests had HGCL on follow-up biopsy. Absence of diagnostic cells was the leading cause for cytology discrepancy and interpretation variances were influenced by marked obscuring inflammation. HPV testing and genotyping had limited value in risk stratification due to extremely low PPV. Focused rescreening of hrHPV-positive NILM with obscuring factors may help reduce interpretation variances.

publication date

  • March 2018

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1002/dc.23874

PubMed ID

  • 29230975

Additional Document Info

start page

  • 239

end page

  • 243

volume

  • 46

number

  • 3