HITs and misses in 100 years of heparin Review uri icon

Overview

MeSH Major

  • Interferon-beta
  • Janus Kinase 2
  • Point Mutation
  • Polycythemia Vera
  • Polyethylene Glycols

abstract

  • Heparin was discovered 100 years ago, and the heparin-induced thrombocytopenia syndrome was described 40 years ago. That the most powerful anticoagulant of the last century can also produce the most extreme prothrombotic diathesis is but one of the paradoxes that surround heparin-induced thrombocytopenia. Standard treatment is alternative anticoagulation. Advances continue to be made regarding pathophysiology, prevention, and treatment. Currently, an epidemic of overdiagnosis threatens the well-being of patients, so efforts to educate clinicians on when and how to make this diagnosis are pressing.

publication date

  • December 8, 2017

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1182/asheducation-2017.1.667

PubMed ID

  • 29222319

Additional Document Info

start page

  • 667

end page

  • 673

volume

  • 2017

number

  • 1