Selective Nanoparticle Targeting of the Renal Tubules Academic Article uri icon

Overview

MeSH Major

  • Kidney Diseases
  • Kidney Tubules, Proximal
  • Nanoparticles

abstract

  • Direct targeting to the kidneys is a promising strategy to improve drug therapeutic index for the treatment of kidney diseases. We sought to investigate the renal selectivity and safety of kidney-targeted mesoscale nanoparticle technology. We found that direct intravenous administration of these particles resulted in 26-fold renal selectivity and localized negligibly in the liver or other organs. The nanoparticles targeted the renal proximal tubular epithelial cells, as evidenced by intravital microscopy and ex vivo imaging. Mice treated with the nanoparticles exhibited no negative systemic consequences, immune reaction, liver impairment, or renal impairment. The localization of material selectively to the renal tubules is uncommon, and this work portends the development of renal-targeted drugs for the treatment of kidney diseases.

publication date

  • January 2018

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC5730475

Digital Object Identifier (DOI)

  • 10.1161/HYPERTENSIONAHA.117.09843

PubMed ID

  • 29133360

Additional Document Info

start page

  • 87

end page

  • 94

volume

  • 71

number

  • 1