Pretargeting of internalizing trastuzumab and cetuximab with a18F-tetrazine tracer in xenograft models Academic Article uri icon

Overview

MeSH Major

  • Fusion Proteins, bcr-abl
  • Piperazines
  • Pyrimidines

abstract

  • We could successfully visualize the tumours by using cetuximab and trastuzumab in pretargeted PET imaging despite the challenging circumstances where the antibody is internalized and there is still some unbound antibody circulating in the blood flow. This clearly demonstrates the potential of a pretargeted approach for targeting internalizing antigens and warrants development of pharmacokinetic optimization of the biorthogonal reactants to this end.

publication date

  • January 2017

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1186/s13550-017-0344-6

PubMed ID

  • 29198065

Additional Document Info

start page

  • 95

volume

  • 7