The updated world health organization glioma classification: Cellular and molecular origins of adult infiltrating gliomas Review uri icon


MeSH Major

  • Central Nervous System Neoplasms
  • Glioma


  • - With multidimensional molecular data sets spanning increasingly larger numbers of patients with infiltrating gliomas, our understanding of the disease at the point of surgical resection has improved dramatically and this understanding is reflected in the updated WHO classification. Animal models have demonstrated a diversity of candidates for glioma cells of origin, but crucial questions remain, including the role of neural stem cells, more differentiated progenitor cells, and glioma stem cells. At this stage the increase in data generated from human samples will hopefully inform the creation of newer animal models that will recapitulate more accurately the diversity of gliomas and provide novel insights into the biologic mechanisms underlying tumor initiation and progression.

publication date

  • December 2017



  • Review



  • eng

Digital Object Identifier (DOI)

  • 10.5858/arpa.2016-0493-RA

PubMed ID

  • 29189064

Additional Document Info

start page

  • 1633

end page

  • 1645


  • 141


  • 12