Current concepts in diagnosis, molecular features, and management of Lobular carcinoma in situ of the breast with a discussion of morphologic variants Review uri icon

Overview

MeSH Major

  • Breast Carcinoma In Situ
  • Breast Neoplasms

abstract

  • - Lobular carcinoma in situ represents a marker for increased risk of breast cancer, as well as a nonobligate precursor to invasive carcinoma. Morphologic variants of LCIS-florid and pleomorphic LCIS-are genetically more-complex lesions and are more likely to be associated with invasive carcinoma. Further investigation into which molecular alterations in LCIS are associated with progression to invasive carcinoma is needed to help guide medical and surgical management.

publication date

  • December 2017

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.5858/arpa.2016-0421-RA

PubMed ID

  • 28574280

Additional Document Info

start page

  • 1668

end page

  • 1678

volume

  • 141

number

  • 12