Effect of early-life fluoxetine on anxiety-like behaviors in BDNF Val66Met mice Academic Article uri icon

Overview

MeSH Major

  • Biocompatible Materials
  • Cell Culture Techniques
  • Neoplasms
  • Neovascularization, Pathologic
  • Oxygen

abstract

  • These findings suggest that SSRI administration during a "sensitive period" during periadolescence leads to long-lasting anxiolytic effects in a genetic mouse model of elevated anxiety-like behaviors. These persistent effects highlight the role of BDNF in the maturation of the serotonin system and the capacity to enhance its development through a pharmacological intervention.

publication date

  • December 2017

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC5711544

Digital Object Identifier (DOI)

  • 10.1176/appi.ajp.2017.15121592

PubMed ID

  • 29084453

Additional Document Info

start page

  • 1203

end page

  • 1213

volume

  • 174

number

  • 12