Risk stratification for prevention of recurrence of postoperative Crohn’s disease Academic Article Article uri icon

Overview

MeSH Major

  • Colitis, Ulcerative
  • Delivery of Health Care

abstract

  • Although there have been significant advances in medical therapies to treat Crohn’s disease, an estimated 50% of patients will require surgery within the first decade of disease duration. Of these patients, a substantial number will develop recurrent symptoms within the first postoperative year. To prevent disease recurrence, many physicians use postoperative prophylactic therapy. Randomized, controlled trials, although limited in number, have demonstrated that a prophylactic postoperative strategy is effective at reducing recurrence (both clinical and endoscopic) in high-risk patients. This article reviews the frequency of and risk factors for postoperative Crohn’s disease recurrence and the current evidence in favor of postoperative Crohn’s disease management strategies. Future studies must be conducted to establish a gold standard as to who should receive postoperative prophylaxis and which therapies and time course are ideal.

publication date

  • November 2017

Research

keywords

  • Academic Article

Identity

PubMed ID

  • 29230144

Additional Document Info

start page

  • 651

end page

  • 658

volume

  • 13

number

  • 11