Illuminating neural circuits: From molecules to MRI Academic Article uri icon

Overview

MeSH Major

  • Coma
  • Consciousness Disorders
  • Electroencephalography
  • Neurologic Examination
  • Subarachnoid Hemorrhage

abstract

  • Neurological disease drives symptoms through pathological changes to circuit functions. Therefore, understanding circuit mechanisms that drive behavioral dysfunction is of critical importance for quantitative diagnosis and systematic treatment of neurological disease. Here, we describe key technologies that enable measurement and manipulation of neural activity and neural circuits. Applying these approaches led to the discovery of circuit mechanisms underlying pathological motor behavior, arousal regulation, and protein accumulation. Finally, we discuss how optogenetic functional magnetic resonance imaging reveals global scale circuit mechanisms, and how circuit manipulations could lead to new treatments of neurological diseases.

publication date

  • November 8, 2017

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1523/JNEUROSCI.2569-17.2017

PubMed ID

  • 29118210

Additional Document Info

start page

  • 10817

end page

  • 10825

volume

  • 37

number

  • 45