Association analysis identifies 65 new breast cancer risk loci Academic Article uri icon

Overview

MeSH Major

  • Breast Neoplasms
  • Genetic Loci
  • Genetic Predisposition to Disease
  • Genome-Wide Association Study

abstract

  • © 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. Breast cancer risk is influenced by rare coding variants in susceptibility genes, such as BRCA1, and many common, mostly non-coding variants. However, much of the genetic contribution to breast cancer risk remains unknown. Here we report the results of a genome-wide association study of breast cancer in 122,977 cases and 105,974 controls of European ancestry and 14,068 cases and 13,104 controls of East Asian ancestry. We identified 65 new loci that are associated with overall breast cancer risk at P < 5 × 10-8. The majority of credible risk single-nucleotide polymorphisms in these loci fall in distal regulatory elements, and by integrating in silico data to predict target genes in breast cells at each locus, we demonstrate a strong overlap between candidate target genes and somatic driver genes in breast tumours. We also find that heritability of breast cancer due to all single-nucleotide polymorphisms in regulatory features was 2-5-fold enriched relative to the genome-wide average, with strong enrichment for particular transcription factor binding sites. These results provide further insight into genetic susceptibility to breast cancer and will improve the use of genetic risk scores for individualized screening and prevention.

authors

publication date

  • November 2, 2017

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC5798588

Digital Object Identifier (DOI)

  • 10.1038/nature24284

PubMed ID

  • 29059683

Additional Document Info

start page

  • 92

end page

  • 94

volume

  • 551

number

  • 7678