Specific Binding of Liposomal Nanoparticles through Inverse Electron-Demand Diels–Alder Click Chemistry Academic Article uri icon


MeSH Major

  • Enzyme Inhibitors
  • Molecular Imaging
  • Single-Cell Analysis


  • Here, we report a method to specifically bind liposomal radiopharmaceuticals to a CoCrMo alloy, which can be used in arterial stents, via an irreversible inverse electron-demand Diels-Alder reaction. Inspired by recent accomplishments in pre-targeted imaging using tetrazine-trans-cyclooctene click chemistry, we synthesized (89)Zr-labeled trans-cyclooctene-functionalized liposomal nanoparticles, which were validated on a tetrazine-appended polydopamine-coated CoCrMo surface. In efforts to ultimately translate this new material to biomedical applications, we compared the ability of (89)Zr-TCO-liposomal nanoparticles ((89)Zr-TCO-LNP) to be immobilized on the tetrazine surface to the control suspensions of non-TCO functionalized (89)Zr-liposomal nanoparticles. Ultimately, this platform technology could result in a systemic decrease of the radiotherapeutic dose deposited in non-targeted tissues by specific removal of long-circulating liposomal radiopharmaceuticals from the blood pool.

publication date

  • October 2017



  • Academic Article



  • eng

PubMed Central ID

  • PMC5641912

Digital Object Identifier (DOI)

  • 10.1002/open.201700105

PubMed ID

  • 29046855

Additional Document Info

start page

  • 615

end page

  • 619


  • 6


  • 5