Adding Polyamine Metabolism to the mTORC1 Toolkit in Cell Growth and Cancer Article uri icon

Overview

MeSH Major

  • Multiprotein Complexes
  • TOR Serine-Threonine Kinases

abstract

  • The mammalian/mechanistic target of rapamycin complex 1 (mTORC1) is a major nutrient sensor and regulator of cellular metabolic flux. Reporting recently in Nature, Zabala-Letona et al. (2017) show that mTORC1 regulates an additional branch of metabolism in the cell-polyamine synthesis-that is important for prostate cancer tumorigenicity.

publication date

  • July 24, 2017

Research

keywords

  • Article

Identity

Digital Object Identifier (DOI)

  • 10.1016/j.devcel.2017.07.004

Additional Document Info

start page

  • 112

end page

  • 114

volume

  • 42

number

  • 2