The interplay between host immune cells and gut microbiota in chronic inflammatory diseases Article Report uri icon

Overview

MeSH Major

  • Asymptomatic Diseases
  • Cerebrovascular Disorders
  • Coronary Artery Disease
  • Peripheral Arterial Disease

abstract

  • Many benefits provided by the gut microbiota to the host rely on its intricate interactions with host cells. Perturbations of the gut microbiota, termed gut dysbiosis, affect the interplay between the gut microbiota and host cells, resulting in dysregulation of inflammation that contributes to the pathogenesis of chronic inflammatory diseases, including inflammatory bowel disease, multiple sclerosis, allergic asthma and rheumatoid arthritis. In this review, we provide an overview of how gut bacteria modulates host metabolic and immune functions, summarize studies that examined the roles of gut dysbiosis in chronic inflammatory diseases, and finally discuss measures to correct gut dysbiosis as potential therapeutics for chronic inflammatory diseases.

publication date

  • May 26, 2017

Research

keywords

  • Report

Identity

Digital Object Identifier (DOI)

  • 10.1038/emm.2017.24

PubMed ID

  • 28546562

Additional Document Info

start page

  • e339

volume

  • 49

number

  • 5