Control of Metastasis by NK Cells. Review uri icon

Overview

MeSH

  • Animals
  • Humans
  • Immunologic Surveillance
  • Immunotherapy
  • Tumor Escape

MeSH Major

  • Killer Cells, Natural
  • Neoplasm Metastasis
  • Neoplasms
  • Tumor Microenvironment

abstract

  • The metastatic spread of malignant cells to distant anatomical locations is a prominent cause of cancer-related death. Metastasis is governed by cancer-cell-intrinsic mechanisms that enable neoplastic cells to invade the local microenvironment, reach the circulation, and colonize distant sites, including the so-called epithelial-to-mesenchymal transition. Moreover, metastasis is regulated by microenvironmental and systemic processes, such as immunosurveillance. Here, we outline the cancer-cell-intrinsic and -extrinsic factors that regulate metastasis, discuss the key role of natural killer (NK) cells in the control of metastatic dissemination, and present potential therapeutic approaches to prevent or target metastatic disease by harnessing NK cells. Copyright © 2017 Elsevier Inc. All rights reserved.

publication date

  • August 14, 2017

has subject area

  • Animals
  • Humans
  • Immunologic Surveillance
  • Immunotherapy
  • Killer Cells, Natural
  • Neoplasm Metastasis
  • Neoplasms
  • Tumor Escape
  • Tumor Microenvironment

Research

keywords

  • Journal Article
  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1016/j.ccell.2017.06.009

PubMed ID

  • 28810142

Additional Document Info

start page

  • 135

end page

  • 154

volume

  • 32

number

  • 2