Using funseq2 for coding and non-coding variant annotation and prioritization Academic Article uri icon

Overview

MeSH Major

  • Adenocarcinoma
  • Carcinoma, Pancreatic Ductal
  • Gene Expression Regulation, Neoplastic
  • Mutation
  • Pancreatic Neoplasms

abstract

  • The identification of non-coding drivers remains a challenge and bottleneck for the use of whole-genome sequencing in the clinic. FunSeq2 is a computational tool for annotation and prioritization of somatic mutations in coding and non-coding regions. It integrates a data context made from large-scale genomic datasets and uses a high-throughput variant prioritization pipeline. This unit provides guidelines for installing and running FunSeq2 to (a) annotate and prioritize variants, (b) incorporate user-defined annotations, and (c) detect differential gene expression. © 2017 by John Wiley & Sons, Inc.

publication date

  • March 2017

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1002/cpbi.23

PubMed ID

  • 28463398

Additional Document Info

start page

  • 15.11.1

end page

  • 15.11.17

volume

  • 2017