Heterogeneous Tumor-Immune Microenvironments among Differentially Growing Metastases in an Ovarian Cancer Patient Academic Article uri icon


MeSH Major

  • Cystadenocarcinoma, Serous
  • Neoplasm Metastasis
  • Ovarian Neoplasms
  • Tumor Microenvironment


  • We present an exceptional case of a patient with high-grade serous ovarian cancer, treated with multiple chemotherapy regimens, who exhibited regression of some metastatic lesions with concomitant progression of other lesions during a treatment-free period. Using immunogenomic approaches, we found that progressing metastases were characterized by immune cell exclusion, whereas regressing and stable metastases were infiltrated by CD8(+) and CD4(+) T cells and exhibited oligoclonal expansion of specific T cell subsets. We also detected CD8(+) T cell reactivity against predicted neoepitopes after isolation of cells from a blood sample taken almost 3 years after the tumors were resected. These findings suggest that multiple distinct tumor immune microenvironments co-exist within a single individual and may explain in part the heterogeneous fates of metastatic lesions often observed in the clinic post-therapy. VIDEO ABSTRACT.

publication date

  • August 24, 2017



  • Academic Article



  • eng

PubMed Central ID

  • PMC5589211

Digital Object Identifier (DOI)

  • 10.1016/j.cell.2017.07.025

PubMed ID

  • 28841418

Additional Document Info

start page

  • 927

end page

  • 938.e20


  • 170


  • 5