Obesity alters the lung myeloid cell landscape to enhance breast cancer metastasis through IL5 and GM-CSF Academic Article uri icon

Overview

MeSH Major

  • Breast Neoplasms
  • Granulocyte-Macrophage Colony-Stimulating Factor
  • Interleukin-5
  • Lung
  • Lung Neoplasms
  • Neutrophil Infiltration
  • Neutrophils
  • Obesity
  • Pneumonia

abstract

  • Obesity is associated with chronic, low-grade inflammation, which can disrupt homeostasis within tissue microenvironments. Given the correlation between obesity and relative risk of death from cancer, we investigated whether obesity-associated inflammation promotes metastatic progression. We demonstrate that obesity causes lung neutrophilia in otherwise normal mice, which is further exacerbated by the presence of a primary tumour. The increase in lung neutrophils translates to increased breast cancer metastasis to this site, in a GM-CSF- and IL5-dependent manner. Importantly, weight loss is sufficient to reverse this effect, and reduce serum levels of GM-CSF and IL5 in both mouse models and humans. Our data indicate that special consideration of the obese patient population is critical for effective management of cancer progression.

publication date

  • August 2017

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1038/ncb3578

PubMed ID

  • 28737771

Additional Document Info

start page

  • 974

end page

  • 987

volume

  • 19

number

  • 8