Molecular imaging of PARP Review uri icon

Overview

MeSH Major

  • Molecular Imaging
  • Neoplasms
  • Poly(ADP-ribose) Polymerases
  • Positron-Emission Tomography
  • Radiopharmaceuticals

abstract

  • The poly(adenosine diphosphate-ribose)polymerase (PARP) family of enzymes is an important factor in the cellular DNA damage response and has gained much attention for its role in many diseases, particularly cancer. Targeted molecular imaging of PARP using fluorescent or radiolabeled tags has followed on the success of therapeutic inhibitors and gained momentum over the past few years. This review covers PARP imaging from the very first imaging agents up to the current state of the technology, with a focus on the clinical applications made possible by these agents.

publication date

  • July 2017

Research

keywords

  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC5493005

Digital Object Identifier (DOI)

  • 10.2967/jnumed.117.189936

PubMed ID

  • 28473593

Additional Document Info

start page

  • 1025

end page

  • 1030

volume

  • 58

number

  • 7