NLRP3 inflammasome deficiency protects against microbial sepsis via increased lipoxin B4 synthesis
Academic Article
Overview
MeSH Major
Carrier Proteins
Inflammasomes
Lipoxins
Sepsis
abstract
Genetic deficiency of NLRP3 promoted resolution of inflammation in polymicrobial sepsis by relieving caspase-7-dependent repression of LXB4 biosynthesis, and increased survival potentially via LXB4 production and inhibition of proinflammatory cytokines.
