NLRP3 inflammasome deficiency protects against microbial sepsis via increased lipoxin B4 synthesis Academic Article uri icon

Overview

MeSH Major

  • Carrier Proteins
  • Inflammasomes
  • Lipoxins
  • Sepsis

abstract

  • Genetic deficiency of NLRP3 promoted resolution of inflammation in polymicrobial sepsis by relieving caspase-7-dependent repression of LXB4 biosynthesis, and increased survival potentially via LXB4 production and inhibition of proinflammatory cytokines.

publication date

  • September 15, 2017

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC5620673

Digital Object Identifier (DOI)

  • 10.1164/rccm.201604-0892OC

PubMed ID

  • 28245134

Additional Document Info

start page

  • 713

end page

  • 726

volume

  • 196

number

  • 6