Driving to Cancer on a Four-Lane Expressway Academic Article uri icon

Overview

MeSH Major

  • Blast Crisis
  • Calreticulin
  • Leukemia, Myeloid, Acute

abstract

  • Recent findings from a prospective clinical study involving multiregion whole-exome sequencing suggest that driver mutations in cancer-relevant genes including EGFR and TP53 are often clonal and precede whole-genome duplication events in early lung carcinogenesis. This paves an expressway to extensive subclonal diversification, elevated intratumoral heterogeneity, and dismal disease outcome.

publication date

  • January 2017

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1016/j.tig.2017.06.003

PubMed ID

  • 28668385

Additional Document Info