TREX1 Cuts Down on Cancer Immunogenicity Academic Article uri icon

Overview

MeSH Major

  • Blast Crisis
  • Calreticulin
  • Leukemia, Myeloid, Acute

abstract

  • Demaria and colleagues have recently identified three prime repair exonuclease 1 (TREX1) as a key determinant for the limited immunogenicity of cancer cells responding to single high-dose radiation. TREX1 stands out as a promising target for the development of novel strategies to boost anticancer immune responses driven by radiation therapy (RT).

publication date

  • January 2017

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1016/j.tcb.2017.06.001

PubMed ID

  • 28625463