Anaesthesia recommendations for patients suffering from Immune thrombocytopenia (ITP) Report uri icon

Overview

MeSH Major

  • Asthma
  • Bronchoalveolar Lavage Fluid
  • Glycoproteins

abstract

  • © 2017 Anästh Intensivmed. Immune thrombocytopenia, previously known as idiopathic thrombocytopenic purpura (ITP), is an autoimmune disease that is related to anti-platelet immunoglobulin (IgG) production. The production of IgG autoantibodies is critically dependent on cellular immune mechanisms particularly relating to T cells. The production of these autoantibodies by B cells depends on a number of cellular mechanisms that form a network of modulation, with T cells playing a pivotal role in pathophysiology. T-cell-mediated cytotoxicity is an alternative mechanism for platelet destruction in ITP [1-3]. Other causes are included genetic factors (immune genes- FcR, immune syndromes, platelet antigens) and susceptibility to initial event (infection, inflamination) [4] . Immune thrombocytopenia is characterised by increased mucocutaneous haemorrhage risk with low platelet counts [5].

publication date

  • May 2017

Research

keywords

  • Report

Identity

Digital Object Identifier (DOI)

  • 10.19224/ai2017.S458

Additional Document Info

start page

  • S458

end page

  • S473

volume

  • 58

number

  • 5