Contribution of systemic and somatic factors to clinical response and resistance to PD-L1 blockade in urothelial cancer: An exploratory multi-omic analysis Academic Article uri icon

Overview

MeSH Major

  • Antibodies, Monoclonal
  • Antigens, CD274
  • Antineoplastic Agents
  • Carcinoma
  • Urologic Neoplasms

abstract

  • These results demonstrate the complex nature of immune response to checkpoint blockade and the compelling need for greater interrogation and data integration of both host and tumor factors. Incorporating these variables in prospective studies will facilitate identification and treatment of resistant patients.

publication date

  • May 2017

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC5446110

Digital Object Identifier (DOI)

  • 10.1371/journal.pmed.1002309

PubMed ID

  • 28552987

Additional Document Info

start page

  • e1002309

volume

  • 14

number

  • 5