Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia Academic Article uri icon

Overview

MeSH Major

  • Autistic Disorder
  • Gene Regulatory Networks
  • Receptors, Metabotropic Glutamate

abstract

  • This study is an important step in the ongoing endeavour to identify the loci which underpin the common variant signal in ASD. In addition to novel GWS loci, we have identified a significant genetic correlation with schizophrenia and association of ASD with several neurodevelopmental-related genes such as EXT1, ASTN2, MACROD2, and HDAC4.

authors

publication date

  • May 22, 2017

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC5441062

Digital Object Identifier (DOI)

  • 10.1186/s13229-017-0137-9

PubMed ID

  • 28540026

Additional Document Info

start page

  • 21

volume

  • 8

number

  • 1