Pharmacological modulation of autophagy: Therapeutic potential and persisting obstacles Review uri icon

Overview

MeSH Major

  • Autophagy
  • Drug Design
  • Neoplasms

abstract

  • Autophagy is central to the maintenance of organismal homeostasis in both physiological and pathological situations. Accordingly, alterations in autophagy have been linked to clinically relevant conditions as diverse as cancer, neurodegeneration and cardiac disorders. Throughout the past decade, autophagy has attracted considerable attention as a target for the development of novel therapeutics. However, such efforts have not yet generated clinically viable interventions. In this Review, we discuss the therapeutic potential of autophagy modulators, analyse the obstacles that have limited their development and propose strategies that may unlock the full therapeutic potential of autophagy modulation in the clinic.

publication date

  • July 2017

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1038/nrd.2017.22

PubMed ID

  • 28529316

Additional Document Info

start page

  • 487

end page

  • 511

volume

  • 16

number

  • 7