HIV Reprograms Human Airway Basal Stem/Progenitor Cells to Acquire a Tissue-Destructive Phenotype. In process uri icon

Overview

abstract

  • While highly active anti-retroviral therapy has dramatically improved the survival of HIV-infected individuals, there is an increased risk for other co-morbidities, such as COPD, manifesting as emphysema. Given that emphysema originates around the airways and that human airway basal cells (BCs) are adult airway stem/progenitor cells, we hypothesized that HIV reprograms BCs to a distinct phenotype that contributes to the development of emphysema. Our data indicate that HIV binds to but does not replicate in BCs. HIV binding to BCs induces them to acquire an invasive phenotype, mediated by upregulation of MMP-9 expression through activation of MAPK signaling pathways. This HIV-induced "destructive" phenotype may contribute to degradation of extracellular matrix and tissue damage relevant to the development of emphysema commonly seen in HIV(+) individuals. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

publication date

  • May 9, 2017

Research

keywords

  • In press

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1016/j.celrep.2017.04.026

PubMed ID

  • 28494859

Additional Document Info

start page

  • 1091

end page

  • 1100

volume

  • 19

number

  • 6