How do messenger RNA splicing alterations drive myelodysplasia? Review uri icon

Overview

MeSH Major

  • Epigenesis, Genetic
  • Myelodysplastic Syndromes
  • Phosphoproteins
  • RNA Splicing
  • RNA Splicing Factors
  • RNA, Messenger

abstract

  • Mutations in RNA splicing factors are the single most common class of genetic alterations in myelodysplastic syndrome (MDS) patients. Although much has been learned about how these mutations affect splicing at a global- and transcript-specific level, critical questions about the role of these mutations in MDS development and maintenance remain. Here we present the questions to be addressed in order to understand the unique enrichment of these mutations in MDS.

publication date

  • May 4, 2017

Research

keywords

  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC5418633

Digital Object Identifier (DOI)

  • 10.1182/blood-2017-02-692715

PubMed ID

  • 28348147

Additional Document Info

start page

  • 2465

end page

  • 2470

volume

  • 129

number

  • 18