Mutant TDP-43 does not impair mitochondrial bioenergetics in vitro and in vivo Academic Article uri icon

Overview

MeSH Major

  • Amyotrophic Lateral Sclerosis
  • Astrocytes
  • Calcium Signaling
  • Exocytosis
  • SNARE Proteins
  • Superoxide Dismutase

abstract

  • While alterations of mitochondrial morphology and dynamics in TDP-43 mutant neurons are well established, the present study did not demonstrate oxidative phosphorylation defects in TDP-43 mutants, in vitro and in vivo. On the other hand, the increase in mitochondrial calcium uptake in A315T TDP-43 mutants was an intriguing finding, which needs to be investigated further to understand its mechanisms and potential pathogenic implications.

publication date

  • May 8, 2017

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC5422931

Digital Object Identifier (DOI)

  • 10.1186/s13024-017-0180-1

PubMed ID

  • 28482850

Additional Document Info

start page

  • 37

volume

  • 12

number

  • 1