Basophil-derived IL-4 promotes epicutaneous antigen sensitization concomitant with the development of food allergy Academic Article uri icon

Overview

MeSH Major

  • Allergens
  • Bronchial Hyperreactivity

abstract

  • TSLP-elicited basophils promote epicutaneous sensitization to food antigens and subsequent IgE-mediated food allergy through IL-4. Strategies to target the TSLP-basophil-IL-4 axis in patients with AD might lead to innovative therapies that can prevent the progression of allergies to distant mucosal sites.

publication date

  • October 14, 2016

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1016/j.jaci.2017.02.035

PubMed ID

  • 28390860

Additional Document Info